Co-dominance is a type of genetic inheritance in which both alleles of a gene are fully expressed in the phenotype of a heterozygous individual. Unlike in dominant-recessive inheritance, where one allele masks the expression of the other, in co-dominance, both alleles contribute equally and are both visible in the organism’s traits.
Co-dominance:
- Definition: In co-dominance, neither allele is dominant or recessive, and both are fully expressed when present together in a heterozygote.
- Outcome: The heterozygous individual shows both traits equally.
Co-dominance in the ABO Blood Group System
The ABO blood group system is an example of co-dominance, where both the A allele and the B allele are co-dominant to each other. The system involves three alleles:
- Iᴬ (A allele): Codes for the A antigen on the surface of red blood cells.
- Iᴮ (B allele): Codes for the B antigen on the surface of red blood cells.
- I⁰ (O allele): Codes for no antigen (recessive allele).
How Co-dominance Works in the ABO Blood System:
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Blood Type Phenotypes:
- A blood type: An individual with IᴬIᴬ or IᴬI⁰ will have A antigens on the surface of their red blood cells.
- B blood type: An individual with IᴮIᴮ or IᴮI⁰ will have B antigens on the surface of their red blood cells.
- AB blood type: An individual with IᴬIᴮ will have both A and B antigens on their red blood cells. This is the result of co-dominance, where both alleles (Iᴬ and Iᴮ) are fully expressed, and the individual has both A and B antigens.
- O blood type: An individual with I⁰I⁰ will have no A or B antigens on their red blood cells.
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Co-dominance in Action:
- Individuals with the IᴬIᴮ genotype (heterozygous for both A and B alleles) will have AB blood type, meaning they will express both the A antigen and the B antigen on their red blood cells. Neither antigen is dominant over the other, and both are visible in the blood type.
Key Points about Co-dominance in the ABO System:
- Iᴬ and Iᴮ alleles are co-dominant, meaning both the A and B antigens are equally and fully expressed in individuals with the IᴬIᴮ genotype.
- I⁰ is recessive to both Iᴬ and Iᴮ, meaning it does not express any antigen and is only visible in the O blood type (I⁰I⁰).
- AB blood type individuals show both A and B antigens, demonstrating co-dominance.