What is co-dominance? Explain with reference to the ABO blood group system.

Co-dominance is a genetic phenomenon where both alleles of a gene are fully expressed in the organism’s phenotype. Unlike in dominance-recessive inheritance, where one allele masks the expression of another, in co-dominance, both alleles contribute equally and are visible in the organism’s traits. This means that neither allele is dominant or recessive, and the heterozygote exhibits traits of both alleles simultaneously.

Co-Dominance:

  • Definition: In co-dominance, both alleles of a gene are expressed equally in the phenotype when they are present together in a heterozygous individual.
  • Outcome: The heterozygous individual shows characteristics of both alleles.

Example: The ABO Blood Group System

The ABO blood group system is a classic example of co-dominance, where the alleles for blood type A and B are co-dominant. Here’s how it works:

  1. The ABO Blood Group Gene:
    The ABO blood group is controlled by a single gene, which has three alleles:

    • Iᴬ (allele A): Codes for the A antigen on the surface of red blood cells.
    • Iᴮ (allele B): Codes for the B antigen on the surface of red blood cells.
    • I⁰ (allele O): Codes for no antigen (i.e., it is recessive to both Iᴬ and Iᴮ).
  2. Genotypes and Phenotypes:

    • IᴬIᴬ or IᴬI⁰: The individual will have A type blood (A antigen on red blood cells).
    • IᴮIᴮ or IᴮI⁰: The individual will have B type blood (B antigen on red blood cells).
    • IᴬIᴮ: The individual will have AB type blood (both A and B antigens are expressed on the red blood cells). This is the example of co-dominance, where both A and B antigens are equally expressed, and the individual has the characteristics of both A and B blood types.
    • I⁰I⁰: The individual will have O type blood (no A or B antigens on the red blood cells).
  3. Co-dominance in Action:
    In individuals with the IᴬIᴮ genotype (heterozygous for both A and B alleles), both the A antigen and B antigen are expressed on the surface of the red blood cells. This results in AB blood type, where both antigens are visible and contribute to the phenotype equally. This is a clear example of co-dominance, where neither allele (Iᴬ or Iᴮ) is dominant over the other, and both contribute to the final blood type.